Heyboer M 3rd, Grant WD, Byrne J, Pons P, Morgan M, Iqbal B, Wojcik SM, et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the Eur.... Date of publication 2014 May 1;volume 22(3):351-5.
1. Wound Repair Regen. 2014 May-Jun;22(3):351-5. doi: 10.1111/wrr.12176.
Hyperbaric oxygen for the treatment of nonhealing arterial insufficiency ulcers.
Heyboer M 3rd(1), Grant WD, Byrne J, Pons P, Morgan M, Iqbal B, Wojcik SM.
Author information:
(1)Department of Emergency Medicine, Division of Hyperbaric Medicine and Wound
Care, SUNY Upstate Medical University, Syracuse, New York.
There is limited data regarding hyperbaric oxygen's effectiveness in the
treatment of nonhealing arterial insufficiency ulcers. This study was designed
to analyze healing rates and amputation rates in patients who underwent
adjunctive hyperbaric oxygen for a nonhealing arterial insufficiency ulcer. A
retrospective chart review was completed on patients who underwent hyperbaric
oxygen for arterial insufficiency ulcers that failed to heal despite standard
treatment. Information collected included complete ulcer healing, amputation,
and patient characteristics. There were 82 patients identified. A majority did
not have diabetes (84.1%). The overall rate of healing was 43.9%. The overall
major amputation rate was 17.1%. The amputation rate among those who healed was
0% compared to 42.4% among those not healed (p < 0.0001). Dialysis was
predictive of major amputation (p = 0.03). Our findings suggest hyperbaric
oxygen can play a role in management of arterial insufficiency ulcers that have
failed standard treatment. The overwhelming majority of these patients did not
have diabetes, which allows this study to be translated to patients with a
primary arterial insufficiency ulcer. These results support the use of
hyperbaric oxygen for select nonhealing arterial insufficiency ulcers that have
failed standard therapy and the need for a prospective pilot study.
© 2014 by the Wound Healing Society.
DOI: 10.1111/wrr.12176
PMID: 24844334 [Indexed for MEDLINE]
