Feitosa MR, Féres Filho O, Tamaki CM, Perazzoli C, Bernardes MV, Parra RS, Rocha JJ, Féres O, et al.
Acta cirurgica brasileira. Date of publication 2016 Jan 1;volume 31 Suppl 1():19-23.
1. Acta Cir Bras. 2016;31 Suppl 1:19-23. doi: 10.1590/S0102-86502016001300005.
Adjunctive Hyperbaric Oxygen Therapy promotes successful healing in patients
with refractory Crohn's disease.
Feitosa MR(1), Féres Filho O(2), Tamaki CM(3), Perazzoli C(1), Bernardes MV(1),
Parra RS(1), Rocha JJ(1), Féres O(1).
Author information:
(1)Department of Surgery and Anatomy, Ribeirão Preto Medical School, University
of São Paulo, Brazil.
(2)School of the Barão, Barão de Mauá University Center, Brazil.
(3)São Paulo Hospital, Brazil.
PURPOSE: To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a
group of patients with refractory Crohn's disease.
METHODS: A total of 29 subjects with refractory Crohn's disease were submitted
to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace
Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2
hours. The endpoint was closure of enterocutaneous fistulas and complete healing
of Pyoderma Gangrenosum and perineal Crohn's disease.
RESULTS: A total of 829 HBOT sessions were performed and no complications were
noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and
enterocutaneous fistulas had the highest successful healing rates (100% and 91%,
respectively). Perineal Crohn's disease healing rate was 65%.
CONCLUSION: Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing
in a group of patients with refractory Crohn's disease.
DOI: 10.1590/S0102-86502016001300005
PMID: 27142900 [Indexed for MEDLINE]
