Rommer EA, Peric M, Wong A, et al.
Advances in skin & wound care. Date of publication 2013 Oct 1;volume 26(10):450-5.
1. Adv Skin Wound Care. 2013 Oct;26(10):450-5. doi:
10.1097/01.ASW.0000434617.57451.e6.
Urinary bladder matrix for the treatment of recalcitrant nonhealing radiation
wounds.
Rommer EA(1), Peric M, Wong A.
Author information:
(1)Elizabeth A. Rommer, BS, is research coordinator; Mirna Peric, BA, is a
research assistant; and Alex Wong, MD, FACS, is assistant professor of surgery,
all in the Division of Plastic and Reconstructive Surgery, Keck School of
Medicine of the University of Southern California, Los Angeles, California.
Chronic wounds in previously radiated tissue are challenging to treat. In this
article, the authors describe 3 such wounds that failed to heal despite multiple
treatments with traditional wound healing methods. Treatment with porcine urinary
bladder matrix, an extracellular matrix material, was initiated to facilitate
epithelialization and promote wound healing. MatriStem powder (ACell, Inc,
Columbia, Maryland), MatriStem (ACell, Inc) sheet, and DuoDerm (ConvaTec,
Skillman, New Jersey) were applied biweekly and resulted in complete wound
closure within 3 weeks of initial application for all 3 cases. All wounds
remained closed 9 months following treatment, suggesting a role for urinary
bladder matrix in the management of chronic wounds in the setting of irradiated
tissue.
DOI: 10.1097/01.ASW.0000434617.57451.e6
PMID: 24045565 [Indexed for MEDLINE]
